(Ro)accutane interacts with receptors of several neurotransmitters that are g-protein coupled, including corresponding hormonal neurosteroids, serotonin, dopamine, norephinephrine, melatonin and GABA. Malfunctioning receptors, decreased receptor expression and lessened metabolism of neurotransmitters are suggested to be effects of a (Ro)accutane exposure. The retinoid signaling found in several parts of the human brain is affected. A significant fall in metabolism has been observed. Cell losses have been suggested. The affected parts of the brain include the hippocampus, orbitofrontal cortex, blood-brain barrier, the subventricular zone and hypothalamus

(Ro)accutane in concentrations that acne-patients are exposed to (>1 microM) results in excessive loss of cells, in several parts of the body and brain, mainly where retinoic acid receptors RARs and RXRs are expressed

(Ro)accutane irreversibly alters the immune-defense in several ways, by altering cytokine production and more. Vitamin A is extensively linked to immune-function. The innate immune system, or the function of several of the receptors that recognize and initiate immune responses are suggested to be significantly altered.

(Ro)accutane is a non- selective, non-reversible toxic acne-"treatment" and therefore has several very severe effects. (Side)-effects ordered alphabetically: Page 1: A-G Page 2: H-S Page 3: T-W and other (side)-effects. List not complete.

Sub-board: Section 5b: Other long term effects

Adolescents is an age group exposed to (Ro)accutane. This during a hormonal peak that occurs. There are several age-related changes in the body and brain. A decline in growth hormone, androgens and other hormones occurs with age. Receptor expression in cells change and so does metabolic activity. Insulin sensitivity changes with age. The long-term effects from (Ro)accutane exposure are unknown. The effects of a (Ro)accutane exposure correlate with the theories that by the scientifical community as a whole, at present are held as an explanation for the development of among other things alzheimers disease, dementia and cognitive decline.

(Ro)accutane, 13-cis-retinoic acid, is a derivate of vitamin A, which although being though of as a vitamin, has very little in common with other vitamins except for vitamin D. In practise vitamin A is a hormone, and is therefore classified as a steroid and inserts its effects through a major influence of gene-expression. Section classifying (Ro)accutane induced transcription by transcription factors and enzymes.

This section is for the beginner, with effects explained in a simplified language.

Aqui hay una explicacion breve de los efectos de Roacutan (Isotretinoina) en Español.

En sammanfattning på svenska av effekter på genomet som induceras av Roaccutan (Isotretinoin), som är en steroid och ett derivat av vitamin A. Flera typer av hormoner påverkas irreversibelt, inkluderande tyroidhormon, vitamin D och A, dihydrotestosteron, progesteron och tillväxthormon. Sammanfattning av effekter på hjärnan.

Information des effets de Roaccutane en français. Résumé d'effets sur le génome, le cerveau et l'immunisé-défense. Roaccutane est une forme de vitamine A et est classifié comme un stéroïde et affecte des récepteurs hormonaux nucléaires dans les cellules.

Wirkungen von Roaccutan. Roaccutan (Vitamin-A-Säure) ist klassifiziert, während ein Steroid mit viele Hormon-(Neben)Wirkungen und andere (Neben)Wirkungen. Zusammenfassung der Wirkungen auf Genom, Gehirn und Immunverteidigung. Resümee ins Deutsch.

Sommario in italiano. Roaccutane è una vitamina ma classificato come uno steroid. Parecchi ormoni sono irreversibilmente riguardati negli soggetti umani esposti. Sommario di effetti sul genoma, gli effetti ormonali, gli effetti sulla difesa immune e gli effetti sul cervello.