Roaccutane Science :: Home News Forum Name Topics Posts Last Post How does the acne and cancer drug (Ro)accutane work chemically? Section 1: Significant irreversible hormonal antagonism (Ro)accutane has a suppressive effect on the steroidogenesis (inhibition of formation of hormones, mainly through inhibition of several pathways in the metabolism of cholesterol), supresses hormonal receptors and cellular uptake. Hormones which action is suppressed include thyroid hormone, growth hormone, testosterone, dihydrotestosterone, progesterone, vitamin D and vitamin A. Circulating hormones which also exist in the brain as neurosteroids, with corresponding receptors located in several parts of the brain. 17 148 on May 5, 2010, 11:01am by dfd in 1.4 Insulin sensitivit... Section 2: Affected neurotransmitters and parts of the brain - 1 Viewing (Ro)accutane interacts with receptors of several neurotransmitters that are g-protein coupled, including corresponding hormonal neurosteroids, serotonin, dopamine, norephinephrine, melatonin and GABA. Malfunctioning receptors, decreased receptor expression and lessened metabolism of neurotransmitters are suggested to be effects of a (Ro)accutane exposure. The retinoid signaling found in several parts of the human brain is affected. A significant fall in metabolism has been observed. Cell losses have been suggested. The affected parts of the brain include the hippocampus, orbitofrontal cortex, blood-brain barrier, the subventricular zone and hypothalamus 14 105 on May 5, 2010, 9:19am by abc in 2. Introduction Section 3: Programmed cell death (apoptosis) (Ro)accutane in concentrations that acne-patients are exposed to (>1 microM) results in excessive loss of cells, in several parts of the body and brain, mainly where retinoic acid receptors RARs and RXRs are expressed 4 23 on May 5, 2010, 9:21am by abc in The RAR/RXR receptor p... Section 4: (Ro)accutane and the immune-defense (Ro)accutane irreversibly alters the immune-defense in several ways, by altering cytokine production and more. Vitamin A is extensively linked to immune-function. The innate immune system, or the function of several of the receptors that recognize and initiate immune responses are suggested to be significantly altered. 11 65 on May 5, 2010, 9:29am by abc in GlcNAc-transferase Section 5: (Side)-effects in subjects exposed to retinoic acid and their suggested causes (A-Z) (1 sub-board) (Ro)accutane is a non- selective, non-reversible toxic acne-"treatment" and therefore has several very severe effects. (Side)-effects ordered alphabetically: Page 1: A-G Page 2: H-S Page 3: T-W and other (side)-effects. List not complete. 57 337 on May 5, 2010, 9:54am by fdjfd in Introduction Section 6: (Ro)accutane effects suggested to worsen with age Adolescents is an age group exposed to (Ro)accutane. This during a hormonal peak that occurs. There are several age-related changes in the body and brain. A decline in growth hormone, androgens and other hormones occurs with age. Receptor expression in cells change and so does metabolic activity. Insulin sensitivity changes with age. The long-term effects from (Ro)accutane exposure are unknown. The effects of a (Ro)accutane exposure correlate with the theories that by the scientifical community as a whole, at present are held as an explanation for the development of among other things alzheimers disease, dementia and cognitive decline. 4 56 on May 5, 2010, 9:59am by dfdf in Cognitive decline, a p... Section 7: Gene-expression (Ro)accutane, 13-cis-retinoic acid, is a derivate of vitamin A, which although being though of as a vitamin, has very little in common with other vitamins except for vitamin D. In practise vitamin A is a hormone, and is therefore classified as a steroid and inserts its effects through a major influence of gene-expression. Section classifying (Ro)accutane induced transcription by transcription factors and enzymes. 6 34 on May 5, 2010, 10:29am by cheap eveing dresses in Significant inhibition... Section 8: (Ro)accutane and its effects explained - for the beginner This section is for the beginner, with effects explained in a simplified language. 3 39 on May 5, 2010, 10:31am by dfdf in Are we missing the poi... Section 9: Los efectos de Roacutan, informacion en español Aqui hay una explicacion breve de los efectos de Roacutan (Isotretinoina) en Español. 2 15 on May 5, 2010, 10:32am by dfd in Resumo em Português Section 10: Effekter inducerade av Roaccutan En sammanfattning på svenska av effekter på genomet som induceras av Roaccutan (Isotretinoin), som är en steroid och ett derivat av vitamin A. Flera typer av hormoner påverkas irreversibelt, inkluderande tyroidhormon, vitamin D och A, dihydrotestosteron, progesteron och tillväxthormon. Sammanfattning av effekter på hjärnan. 4 28 on May 5, 2010, 10:34am by dfd in Innocent Knitting Section 11: Information des effets a persuade de Roaccutane en français. Information des effets de Roaccutane en français. Résumé d'effets sur le génome, le cerveau et l'immunisé-défense. Roaccutane est une forme de vitamine A et est classifié comme un stéroïde et affecte des récepteurs hormonaux nucléaires dans les cellules. 3 19 on May 5, 2010, 10:37am by dfd in Under The Table Section 12: Wirkungen von Roaccutan (isotretinoin) Wirkungen von Roaccutan. Roaccutan (Vitamin-A-Säure) ist klassifiziert, während ein Steroid mit viele Hormon-(Neben)Wirkungen und andere (Neben)Wirkungen. Zusammenfassung der Wirkungen auf Genom, Gehirn und Immunverteidigung. Resümee ins Deutsch. 3 14 on May 5, 2010, 10:38am by dfd in Suspicious Mother Section 13: Gli effetti da Roaccutan Sommario in italiano. Roaccutane è una vitamina ma classificato come uno steroid. Parecchi ormoni sono irreversibilmente riguardati negli soggetti umani esposti. Sommario di effetti sul genoma, gli effetti ormonali, gli effetti sulla difesa immune e gli effetti sul cervello. 1 8 on May 5, 2010, 10:40am by dfdfa in Gli effetti da Roaccutan Section 14: Resultaten van Roaccutan Roaccutan is een formulier van vitamine A, maar classificeerde als een steroïde en nucleaire hormonale receptoren in de cel treft. Samenvatting in Nederlands van resultaten op hormonale resultaten, bewerkstelligt op het genoom, brein en immuun-verdediging 5 27 on May 5, 2010, 10:42am by dfdf in Christmas Love! Discussion of treatments of (Ro)accutane (side)-effects Links Links Useful links 2 4 on May 5, 2010, 10:43am by dfd in Research links Non commercial forum, no recommendation of marked products through banners General General Board - 1 Viewing You can talk about anything here Moderator: Max 22 85 on Jul 1, 2010, 8:41pm by larryp7639 in Does the use of accuta... 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Stay logged in for: 15 minutes30 minutes1 hour2 hours4 hours6 hours12 hours1 day1 weekForever Forum Jump--------------------» Home--------------------» How does the acne and cancer drug (Ro)accutane work chemically?--------------------- Section 1: Significant irreversible hormonal antagonism- Section 2: Affected neurotransmitters and parts of the brain- Section 3: Programmed cell death (apoptosis)- Section 4: (Ro)accutane and the immune-defense- Section 5: (Side)-effects in subjects exposed to retinoic acid and their suggested causes (A-Z) --- Section 5b: Other long term effects- Section 6: (Ro)accutane effects suggested to worsen with age- Section 7: Gene-expression- Section 8: (Ro)accutane and its effects explained - for the beginner- Section 9: Los efectos de Roacutan, informacion en español- Section 10: Effekter inducerade av Roaccutan - Section 11: Information des effets a persuade de Roaccutane en français.- Section 12: Wirkungen von Roaccutan (isotretinoin) - Section 13: Gli effetti da Roaccutan- Section 14: Resultaten van Roaccutan--------------------» Discussion of treatments of (Ro)accutane (side)-effects----------------------------------------» Links--------------------- Links--------------------» Non commercial forum, no recommendation of marked products through banners----------------------------------------» General--------------------- General Board