Roaccutane Science :: Home News Forum Name Topics Posts Last Post How does the acne and cancer drug (Ro)accutane work chemically? Section 1: Significant irreversible hormonal antagonism (Ro)accutane has a suppressive effect on the steroidogenesis (inhibition of formation of hormones, mainly through inhibition of several pathways in the metabolism of cholesterol), supresses hormonal receptors and cellular uptake. Hormones which action is suppressed include thyroid hormone, growth hormone, testosterone, dihydrotestosterone, progesterone, vitamin D and vitamin A. Circulating hormones which also exist in the brain as neurosteroids, with corresponding receptors located in several parts of the brain. 16 65 on Sept 12, 2009, 5:47am by paul scott in Distressed Mother Section 2: Affected neurotransmitters and parts of the brain (Ro)accutane interacts with receptors of several neurotransmitters that are g-protein coupled, including corresponding hormonal neurosteroids, serotonin, dopamine, norephinephrine, melatonin and GABA. Malfunctioning receptors, decreased receptor expression and lessened metabolism of neurotransmitters are suggested to be effects of a (Ro)accutane exposure. The retinoid signaling found in several parts of the human brain is affected. A significant fall in metabolism has been observed. Cell losses have been suggested. The affected parts of the brain include the hippocampus, orbitofrontal cortex, blood-brain barrier, the subventricular zone and hypothalamus 14 63 on Aug 5, 2009, 10:17pm by ddddyyyy in 2.2 Affected neurotran... Section 3: Programmed cell death (apoptosis) (Ro)accutane in concentrations that acne-patients are exposed to (>1 microM) results in excessive loss of cells, in several parts of the body and brain, mainly where retinoic acid receptors RARs and RXRs are expressed 4 11 on Jul 19, 2005, 10:24am by Max in Programmed cell death ... Section 4: (Ro)accutane and the immune-defense (Ro)accutane irreversibly alters the immune-defense in several ways, by altering cytokine production and more. Vitamin A is extensively linked to immune-function. The innate immune system, or the function of several of the receptors that recognize and initiate immune responses are suggested to be significantly altered. 11 32 on Jul 6, 2006, 3:57pm by Candelaria and son Vincent in GlcNAc-transferase Section 5: (Side)-effects in subjects exposed to retinoic acid and their suggested causes (A-Z) (1 sub-board) (Ro)accutane is a non- selective, non-reversible toxic acne-"treatment" and therefore has several very severe effects. (Side)-effects ordered alphabetically: Page 1: A-G Page 2: H-S Page 3: T-W and other (side)-effects. List not complete. 57 187 on Oct 24, 2009, 4:50am by skintel in (Ro)accutane and the skin Section 6: (Ro)accutane effects suggested to worsen with age Adolescents is an age group exposed to (Ro)accutane. This during a hormonal peak that occurs. There are several age-related changes in the body and brain. A decline in growth hormone, androgens and other hormones occurs with age. Receptor expression in cells change and so does metabolic activity. Insulin sensitivity changes with age. The long-term effects from (Ro)accutane exposure are unknown. The effects of a (Ro)accutane exposure correlate with the theories that by the scientifical community as a whole, at present are held as an explanation for the development of among other things alzheimers disease, dementia and cognitive decline. 4 36 on Sept 6, 2009, 10:16pm by ddddyyyy in Serotonin transport an... Section 7: Gene-expression (Ro)accutane, 13-cis-retinoic acid, is a derivate of vitamin A, which although being though of as a vitamin, has very little in common with other vitamins except for vitamin D. In practise vitamin A is a hormone, and is therefore classified as a steroid and inserts its effects through a major influence of gene-expression. Section classifying (Ro)accutane induced transcription by transcription factors and enzymes. 6 17 on Sept 30, 2006, 4:17pm by Alexandre in Significant inhibition... Section 8: (Ro)accutane and its effects explained - for the beginner This section is for the beginner, with effects explained in a simplified language. 2 27 on Sept 4, 2009, 4:12am by forum in 1. Hormones and gene-e... Section 9: Los efectos de Roacutan, informacion en español Aqui hay una explicacion breve de los efectos de Roacutan (Isotretinoina) en Español. 2 5 on Sept 17, 2005, 6:05pm by Max in Resumo em Português Section 10: Effekter inducerade av Roaccutan En sammanfattning på svenska av effekter på genomet som induceras av Roaccutan (Isotretinoin), som är en steroid och ett derivat av vitamin A. Flera typer av hormoner påverkas irreversibelt, inkluderande tyroidhormon, vitamin D och A, dihydrotestosteron, progesteron och tillväxthormon. Sammanfattning av effekter på hjärnan. 4 16 on Mar 18, 2009, 2:11am by f56d5r in Innocent Knitting Section 11: Information des effets a persuade de Roaccutane en français. Information des effets de Roaccutane en français. Résumé d'effets sur le génome, le cerveau et l'immunisé-défense. Roaccutane est une forme de vitamine A et est classifié comme un stéroïde et affecte des récepteurs hormonaux nucléaires dans les cellules. 3 8 on Mar 18, 2009, 2:10am by gf52t5 in Under The Table Section 12: Wirkungen von Roaccutan (isotretinoin) Wirkungen von Roaccutan. Roaccutan (Vitamin-A-Säure) ist klassifiziert, während ein Steroid mit viele Hormon-(Neben)Wirkungen und andere (Neben)Wirkungen. Zusammenfassung der Wirkungen auf Genom, Gehirn und Immunverteidigung. Resümee ins Deutsch. 3 5 on Mar 25, 2009, 8:56pm by 56f5hd5 in Suspicious Mother Section 13: Gli effetti da Roaccutan Sommario in italiano. Roaccutane è una vitamina ma classificato come uno steroid. Parecchi ormoni sono irreversibilmente riguardati negli soggetti umani esposti. Sommario di effetti sul genoma, gli effetti ormonali, gli effetti sulla difesa immune e gli effetti sul cervello. 1 4 on Oct 20, 2008, 3:16am by Misa in Gli effetti da Roaccutan Section 14: Resultaten van Roaccutan Roaccutan is een formulier van vitamine A, maar classificeerde als een steroïde en nucleaire hormonale receptoren in de cel treft. Samenvatting in Nederlands van resultaten op hormonale resultaten, bewerkstelligt op het genoom, brein en immuun-verdediging 5 7 on Mar 25, 2009, 8:56pm by gf52t5 in Under The Table Discussion of treatments of (Ro)accutane (side)-effects Links Links Useful links 2 2 on Aug 19, 2005, 6:58am by Max in Summarizing studies of... Non commercial forum, no recommendation of marked products through banners General General Board You can talk about anything here Moderator: Max 22 56 on Nov 20, 2006, 9:01am by emmajt in Possible treatment tha... Info Center Forum Statistics Total Topics: 156   -   Total Posts: 541 Last Updated Topic: (Ro)accutane and the skin by skintel (Oct 24, 2009, 4:50am) View the 20 most recent posts of this forum. Total Members: 59 Newest Member: skintel Users Online 0 Members, 2 Guests. Most users online was 226, Dec 14, 2008, 11:09am Active Users In The Past 24 Hours 0 Members, 49 Guests Login Username: Create New Account Password: Forgot Your Password? Stay logged in for: 15 minutes30 minutes1 hour2 hours4 hours6 hours12 hours1 day1 weekForever Forum Jump--------------------» Home--------------------» How does the acne and cancer drug (Ro)accutane work chemically?--------------------- Section 1: Significant irreversible hormonal antagonism- Section 2: Affected neurotransmitters and parts of the brain- Section 3: Programmed cell death (apoptosis)- Section 4: (Ro)accutane and the immune-defense- Section 5: (Side)-effects in subjects exposed to retinoic acid and their suggested causes (A-Z) --- Section 5b: Other long term effects- Section 6: (Ro)accutane effects suggested to worsen with age- Section 7: Gene-expression- Section 8: (Ro)accutane and its effects explained - for the beginner- Section 9: Los efectos de Roacutan, informacion en español- Section 10: Effekter inducerade av Roaccutan - Section 11: Information des effets a persuade de Roaccutane en français.- Section 12: Wirkungen von Roaccutan (isotretinoin) - Section 13: Gli effetti da Roaccutan- Section 14: Resultaten van Roaccutan--------------------» Discussion of treatments of (Ro)accutane (side)-effects----------------------------------------» Links--------------------- Links--------------------» Non commercial forum, no recommendation of marked products through banners----------------------------------------» General--------------------- General Board