Roaccutane Science :: How does the acne and cancer drug (Ro)accutane work chemically? :: Section 5: (Side)-effects in subjects exposed to retinoic acid and their suggested causes (A-Z) :: (Ro)accutane and the skin Author Topic: (Ro)accutane and the skin (Read 417 times) Max Administrator member is offline Joined: Apr 2005 Gender: Male Posts: 576 (Ro)accutane and the skin « Thread Started on Jul 13, 2005, 5:50am » (Ro)accutane induced aging skin due to hormonal deficits Intrinsic skin aging is determined primarily by genetic factors and hormonal status. It reflects the same degenerative process seen in other organs. Skin function is one of the parameters most influenced by aging. The hormonal influences include reduced pituitary, adrenal and gonadal secretion. The hormonal changes of aging lead to the development of a specific body and skin phenotype. Individuals in developed lands spend up to a third of their life (women-post-menopausal) or perhaps 20 years (men-partial androgen deficiency of the aging man, PADAM) with oestrogen or androgen deficiency. Other hormones whose levels decrease with aging include melatonin, growth hormone (GH), dehydroepiandrosterone und insulin-like growth factor-I (IGF-I). Since the skin not only fulfils a protective function for the organism but is also an active peripheral endocrine organ, which even releases effective hormones in the circulation, local hormone substitution could become interesting in the future [1]. (Ro)accutane induced skin fragility The origin and frequency of skin fragility, a frequent side effect of oral synthetic retinoids, was studied in ten patients receiving isotretinoin (13-cis-retinoic acid) for disorders of keratinization and in hairless mice treated with isotretinoin and the aromatic retinoid, etretinate (RO 10-9359). Clinical skin fragility occurred in eight of ten patients, and experimental friction blisters could be induced by pencil eraser abrasion in nine of nine patients and in the hairless mice. Light and electron microscopy of friction blisters showed fraying or loss of the stratum corneum and outer layers of the viable epidermis, loss of desmosomes and tonofilaments, and intracellular and intercellular deposits of amorphous material that did not stain with stains for mucin. The skin fragility produced by oral synthetic retinoids is epidermal in origin, since retinoids induce profound disruption of epidermal morphologic appearance [2]. « Last Edit: Aug 28, 2005, 3:05pm by Max » Link to Post - Back to Top   Logged Max Administrator member is offline Joined: Apr 2005 Gender: Male Posts: 576 Re: (Ro)accutane and the skin « Reply #1 on Jul 13, 2005, 5:51am » b Link to Post - Back to Top   Logged Max Administrator member is offline Joined: Apr 2005 Gender: Male Posts: 576 Re: (Ro)accutane and the skin « Reply #2 on Jul 13, 2005, 5:51am » c Link to Post - Back to Top   Logged Max Administrator member is offline Joined: Apr 2005 Gender: Male Posts: 576 Re: (Ro)accutane and the skin « Reply #3 on Jul 13, 2005, 5:51am » d Link to Post - Back to Top   Logged Max Administrator member is offline Joined: Apr 2005 Gender: Male Posts: 576 Re: (Ro)accutane and the skin « Reply #4 on Jul 13, 2005, 5:52am » e Link to Post - Back to Top   Logged Max Administrator member is offline Joined: Apr 2005 Gender: Male Posts: 576 Re: (Ro)accutane and the skin « Reply #5 on Jul 13, 2005, 5:52am » References: [1] Zouboulis ChC. [Intrinsic skin aging. A critical appraisal of the role of hormones] (2003) Hautarzt. Sep;54(9):825-32. [2] Williams ML, Elias PM. Nature of skin fragility in patients receiving retinoids for systemic effect. (1981) Arch Dermatol. Oct;117(10):611-9. « Last Edit: Aug 28, 2005, 3:06pm by Max » Link to Post - Back to Top   Logged skintel New Member member is offline Joined: Oct 2009 Posts: 1 Re: (Ro)accutane and the skin « Reply #6 on Oct 24, 2009, 4:50am » can someone please please email me these articles? my school does not have access to them because the are backfiles ... they can be found through pub med but they are from the archives of dermatology. my email is accutangedamage @ gmail Link to Post - Back to Top   Logged ghd Guest Re: (Ro)accutane and the skin « Reply #7 on Nov 19, 2009, 3:34am » true religion wholesale replica nfl jerseys ed hardy shirt jordan shoes jordan shoes wholesale cheap jordans ed hardy shirt replica watches wholesale jordan shoes ed hardy wholesale bose in-ear headphones coach handbags electronic cigarette replica handbags wholesale nike shoes wholesale nike dunks wholesale jerseys nfl jersey abercrombie fitch wholesale ed hardy clothing nfl jerseys wholesale nfl jersey GHD nhl jerseys nfl jerseys nfl jerseys wholesale nfl jerseys wholesale tomic weight loss tips Link to Post - Back to Top   Logged weight Guest Re: (Ro)accutane and the skin « Reply #8 on Nov 19, 2009, 3:42am » healthy weight loss natural weight loss quick weight loss weight loss calculator weight loss diet weight loss exercise weight loss pills weight loss plans weight loss programs weight loss Link to Post - Back to Top   Logged Forum Jump--------------------» Home--------------------» How does the acne and cancer drug (Ro)accutane work chemically?--------------------- Section 1: Significant irreversible hormonal antagonism- Section 2: Affected neurotransmitters and parts of the brain- Section 3: Programmed cell death (apoptosis)- Section 4: (Ro)accutane and the immune-defense- Section 5: (Side)-effects in subjects exposed to retinoic acid and their suggested causes (A-Z) --- Section 5b: Other long term effects- Section 6: (Ro)accutane effects suggested to worsen with age- Section 7: Gene-expression- Section 8: (Ro)accutane and its effects explained - for the beginner- Section 9: Los efectos de Roacutan, informacion en español- Section 10: Effekter inducerade av Roaccutan - Section 11: Information des effets a persuade de Roaccutane en français.- Section 12: Wirkungen von Roaccutan (isotretinoin) - Section 13: Gli effetti da Roaccutan- Section 14: Resultaten van Roaccutan--------------------» Discussion of treatments of (Ro)accutane (side)-effects----------------------------------------» Links--------------------- Links--------------------» Non commercial forum, no recommendation of marked products through banners----------------------------------------» General--------------------- General Board