Section 1: Significant irreversible hormonal antagonism

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Section 1: Significant irreversible hormonal antagonism
(Ro)accutane has a suppressive effect on the steroidogenesis (inhibition of formation of hormones, mainly through inhibition of several pathways in the metabolism of cholesterol), supresses hormonal receptors and cellular uptake. Hormones which action is suppressed include thyroid hormone, growth hormone, testosterone, dihydrotestosterone, progesterone, vitamin D and vitamin A. Circulating hormones which also exist in the brain as neurosteroids, with corresponding receptors located in several parts of the brain.
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