Welcome to Roaccutane Science, a scientifical non-commercial forum for dermatologists and the publics right of access to (Ro)accutane induced effects and the consequences of exposure

How does the acne and cancer drug (Ro)accutane work chemically?

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No New Posts Section 1: Significant irreversible hormonal antagonism

(Ro)accutane has a suppressive effect on the steroidogenesis (inhibition of formation of hormones, mainly through inhibition of several pathways in the metabolism of cholesterol), supresses hormonal receptors and cellular uptake. Hormones which action is suppressed include thyroid hormone, growth hormone, testosterone, dihydrotestosterone, progesterone, vitamin D and vitamin A. Circulating hormones which also exist in the brain as neurosteroids, with corresponding receptors located in several parts of the brain.

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by calsuroodockri
Oct 18, 2021 4:40:09 GMT -5
No New Posts Section 2: Affected neurotransmitters and parts of the brain

(Ro)accutane interacts with receptors of several neurotransmitters that are g-protein coupled, including corresponding hormonal neurosteroids, serotonin, dopamine, norephinephrine, melatonin and GABA. Malfunctioning receptors, decreased receptor expression and lessened metabolism of neurotransmitters are suggested to be effects of a (Ro)accutane exposure. The retinoid signaling found in several parts of the human brain is affected. A significant fall in metabolism has been observed. Cell losses have been suggested. The affected parts of the brain include the hippocampus, orbitofrontal cortex, blood-brain barrier, the subventricular zone and hypothalamus

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by haylinfuddskywen
Nov 25, 2021 18:31:31 GMT -5
No New Posts Section 3: Programmed cell death (apoptosis)

(Ro)accutane in concentrations that acne-patients are exposed to (>1 microM) results in excessive loss of cells, in several parts of the body and brain, mainly where retinoic acid receptors RARs and RXRs are expressed

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by terpymotedown
Oct 26, 2021 7:48:41 GMT -5
No New Posts Section 4: (Ro)accutane and the immune-defense

(Ro)accutane irreversibly alters the immune-defense in several ways, by altering cytokine production and more. Vitamin A is extensively linked to immune-function. The innate immune system, or the function of several of the receptors that recognize and initiate immune responses are suggested to be significantly altered.

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by turkeyvisa00120
Apr 10, 2022 11:24:18 GMT -5
No New Posts Section 5: (Side)-effects in subjects exposed to retinoic acid and their suggested causes (A-Z)

(Ro)accutane is a non- selective, non-reversible toxic acne-"treatment" and therefore has several very severe effects. (Side)-effects ordered alphabetically: Page 1: A-G Page 2: H-S Page 3: T-W and other (side)-effects. List not complete.

Sub-board: Section 5b: Other long term effects

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by feigceninrala
Oct 15, 2021 15:33:46 GMT -5
No New Posts Section 6: (Ro)accutane effects suggested to worsen with age

Adolescents is an age group exposed to (Ro)accutane. This during a hormonal peak that occurs. There are several age-related changes in the body and brain. A decline in growth hormone, androgens and other hormones occurs with age. Receptor expression in cells change and so does metabolic activity. Insulin sensitivity changes with age. The long-term effects from (Ro)accutane exposure are unknown. The effects of a (Ro)accutane exposure correlate with the theories that by the scientifical community as a whole, at present are held as an explanation for the development of among other things alzheimers disease, dementia and cognitive decline.

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by terpymotedown
Oct 26, 2021 7:45:40 GMT -5
No New Posts Section 7: Gene-expression

(Ro)accutane, 13-cis-retinoic acid, is a derivate of vitamin A, which although being though of as a vitamin, has very little in common with other vitamins except for vitamin D. In practise vitamin A is a hormone, and is therefore classified as a steroid and inserts its effects through a major influence of gene-expression. Section classifying (Ro)accutane induced transcription by transcription factors and enzymes.

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by haylinfuddskywen
Nov 25, 2021 18:08:06 GMT -5
No New Posts Section 8: (Ro)accutane and its effects explained - for the beginner

This section is for the beginner, with effects explained in a simplified language.

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by haylinfuddskywen
Nov 25, 2021 18:14:01 GMT -5
No New Posts Section 9: Los efectos de Roacutan, informacion en español

Aqui hay una explicacion breve de los efectos de Roacutan (Isotretinoina) en Español.

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by calsuroodockri
Oct 18, 2021 4:58:04 GMT -5
No New Posts Section 10: Effekter inducerade av Roaccutan

En sammanfattning på svenska av effekter på genomet som induceras av Roaccutan (Isotretinoin), som är en steroid och ett derivat av vitamin A. Flera typer av hormoner påverkas irreversibelt, inkluderande tyroidhormon, vitamin D och A, dihydrotestosteron, progesteron och tillväxthormon. Sammanfattning av effekter på hjärnan.

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by haylinfuddskywen
Nov 25, 2021 18:34:21 GMT -5
No New Posts Section 11: Information des effets a persuade de Roaccutane en français.

Information des effets de Roaccutane en français. Résumé d'effets sur le génome, le cerveau et l'immunisé-défense. Roaccutane est une forme de vitamine A et est classifié comme un stéroïde et affecte des récepteurs hormonaux nucléaires dans les cellules.

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by haylinfuddskywen
Nov 25, 2021 18:25:34 GMT -5
No New Posts Section 12: Wirkungen von Roaccutan (isotretinoin)

Wirkungen von Roaccutan. Roaccutan (Vitamin-A-Säure) ist klassifiziert, während ein Steroid mit viele Hormon-(Neben)Wirkungen und andere (Neben)Wirkungen. Zusammenfassung der Wirkungen auf Genom, Gehirn und Immunverteidigung. Resümee ins Deutsch.

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by haylinfuddskywen
Nov 25, 2021 18:19:50 GMT -5
No New Posts Section 13: Gli effetti da Roaccutan

Sommario in italiano. Roaccutane è una vitamina ma classificato come uno steroid. Parecchi ormoni sono irreversibilmente riguardati negli soggetti umani esposti. Sommario di effetti sul genoma, gli effetti ormonali, gli effetti sulla difesa immune e gli effetti sul cervello.

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by haylinfuddskywen
Nov 25, 2021 18:28:32 GMT -5
No New Posts Section 14: Resultaten van Roaccutan

Roaccutan is een formulier van vitamine A, maar classificeerde als een steroïde en nucleaire hormonale receptoren in de cel treft. Samenvatting in Nederlands van resultaten op hormonale resultaten, bewerkstelligt op het genoom, brein en immuun-verdediging

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by terpymotedown
Oct 26, 2021 7:39:29 GMT -5

Discussion of treatments of (Ro)accutane (side)-effects

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