Post by Max on Jul 17, 2005 15:28:38 GMT -5
Effects on salivary glands, salive secretion and salivary enzymes
In rat submandibular salivary gland (SMSG) homogenates, the activity of (Na+ + K+)-ATPase was reduced after exposure to 13-cis retinoic acid. Fatty acid composition of total lipids in SMSG suggest that decrease in (Na+ + K+)-ATPase activity may be associated with changes in fatty acid composition of total lipids [1]. Mouth dryness and decreased flow rate of saliva is a common effect during exposure. Cases of irreversible xerostomia have been associated with previous exposure [2]. Activity of metaloproteinase 9 (MMP-9) has been found to be significantly altered in human subjects exposed to (Ro)accutane during exposure [3]. The long term effects on the function of salivary enzymes in subjects exposed to (Ro)accutane is unknown.
In rat submandibular salivary gland (SMSG) homogenates, the activity of (Na+ + K+)-ATPase was reduced after exposure to 13-cis retinoic acid. Fatty acid composition of total lipids in SMSG suggest that decrease in (Na+ + K+)-ATPase activity may be associated with changes in fatty acid composition of total lipids [1]. Mouth dryness and decreased flow rate of saliva is a common effect during exposure. Cases of irreversible xerostomia have been associated with previous exposure [2]. Activity of metaloproteinase 9 (MMP-9) has been found to be significantly altered in human subjects exposed to (Ro)accutane during exposure [3]. The long term effects on the function of salivary enzymes in subjects exposed to (Ro)accutane is unknown.
