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Post by Max on Jun 12, 2005 13:48:40 GMT -5
Six weeks of isotretinoin treatment caused a statistically significant 19% increase in suction blister fluid TGF-beta1. [2] Glycosylphosphatidylinositol (GPI)-anchored proteins have been demonstrated to bind transforming growth factor-beta (TGF-beta) in certain cell lines. GPI-anchored protein(s) are suggested to inhibit TGF-beta signaling and implicate r150 as the GPI-anchored protein responsible for this inhibition in human keratinocytes [1]. TGF-beta1 was found to significantly down-regulate IP3R protein expression in mesanglial cells[5].
mRNA levels of the type 1 IP3 receptors were found to be decreased significantly in cerebellum and hypothalamus, but not in the brain stem of rats treated with retinoic acid, compared to untreated littermates. The mRNA levels of the type 2 IP3 receptor were significantly decreased in all tested tissues, cerebellum, hypothalamus, and also in brain stem after the treatment with retinoic acid. These results show that gene expression of both type 1 and 2 IP3 receptors is regulated by retinoic acid, although the effect of retinoic acid on mRNA levels of the type 1 IP3 receptors is dependent on brain area. [4]
IP(3) receptor channel clusters control Ca(2+) intracellular release from the endoplasmic reticulum (ER) to the cytosol in various cells and species. [3]
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Post by Max on Jun 12, 2005 13:49:16 GMT -5
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Post by Max on Jun 12, 2005 13:50:00 GMT -5
References:
[1] Tam BY, Finnson KW, Philip A. Glycosyl-phosphatidylinositol-anchored proteins regulate transforming growth factor-beta signaling in human keratinocytes. (2003) J Biol Chem. Dec 5;278(49):49610-7.
[2] Leivo T, Arjomaa P, Oivula J, Vesterinen M, Kiistala U, Autio P, Oikarinen A. Differential modulation of transforming growth factor-beta by betamethasone-17- valerate and isotretinoin: corticosteroid decreases and isotretinoin increases the level of transforming growth factor-beta in suction blister fluid. (2000) Skin Pharmacol Appl Skin Physiol. May-Aug;13(3-4):150-6.
[3] Thul R, Falcke M. Release currents of IP(3) receptor channel clusters and concentration profiles. (2004) Biophys J. May;86(5):2660-73.
[4] Stefanik P, Macejova D, Mravec B, Brtko J, Krizanova O. Distinct modulation of a gene expression of the type 1 and 2 IP(3) receptors by retinoic acid in brain areas. (2005) Neurochem Int. Jun;46(7):559-64.
[5] Sharma K, Wang L, Zhu Y, Bokkala S, Joseph SK. Transforming growth factor-beta1 inhibits type I inositol 1,4,5-trisphosphate receptor expression and enhances its phosphorylation in mesangial cells. (1997) J Biol Chem. Jun 6;272(23):14617-23.
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