Post by Max on Jul 13, 2005 7:22:17 GMT -5
Hoffman la Roche itself has unconditionally been forced to admit to (Ro)accutane induced birth defects in child-bearing women exposed to the toxin [0]. (Ro)accutane is also, currently up to this date, used in subjects with infantile acne [4 and more]. In infantile exposure the dose of isotretinoin used ranged from 0.2 mg/kg/day to 1.5 mg/kg/day [4].
Birth defects have been verified by extensive independent case reports [1, 2, 3 and more]. However, it is not the aim of this forum to provide scientifical explanations for (Ro)accutane induced birth defects. The focus of this forum is solely directed to effects in the adult and adolescent subjects exposed to the toxin.
References:
[0] No author Roche official complete US Accutane Product information www.rocheusa.com/products/accutane/pi.pdf
[1]
[2]
[3]
[4] Barnes CJ, Eichenfield LF, Lee J, Cunningham BB. A practical approach for the use of oral isotretinoin for infantile acne. (2005) Pediatr Dermatol. Mar-Apr;22(2):166-9.
Birth defects have been verified by extensive independent case reports [1, 2, 3 and more]. However, it is not the aim of this forum to provide scientifical explanations for (Ro)accutane induced birth defects. The focus of this forum is solely directed to effects in the adult and adolescent subjects exposed to the toxin.
References:
[0] No author Roche official complete US Accutane Product information www.rocheusa.com/products/accutane/pi.pdf
[1]
[2]
[3]
[4] Barnes CJ, Eichenfield LF, Lee J, Cunningham BB. A practical approach for the use of oral isotretinoin for infantile acne. (2005) Pediatr Dermatol. Mar-Apr;22(2):166-9.