Post by Max on Jul 15, 2005 5:42:58 GMT -5
General effects decreased metabolism in all studied acne subjects after four monts of (Ro)accutane exposure
A strong degeneration of several parts of the body and brain has been found in all examined subjects exposed to (Ro)accutane, whereas it is highly likely that these effects are general. Significantly decreased metabolism in the orbitofrontal cortex was found in all human subjects examined after exposure to (Ro)accutane (-21%) [1].
Picture 1. Bremner JD et al. Functional brain imaging alterations in acne patients treated with isotretinoin. (2005) Am J Psychiatry. May;162(5):983-91.
Doubled oxidative stress measured by 8-OHdG allready at half the maximum dose in acne-subjects
Human subjects with CA (n=18) were evaluated before and 45 days after Iso (0.5mg/kg per day) exposure and non-diseased controls (n=22) were tested only once. Plasma TAS levels and 8-OHdG were measured spectrophotometrically and with an immunoassay, respectively. Liver biochemical parameters and muscle enzymes were measured on a blood chemistry analyzer. Results: TAS levels were significantly (p<0.0001) lower in patients before treatment (921+/-124 mumol/L) compared with those after treatment (1335+/-93 mumol/L) and in controls (1536+/-126 mumol/L). In contrast, 8-OHdG serum levels were two-fold higher in patients after exposure (0.21+/-0.03 ng/mL) than before exposure (0.11+/-0.02 ng/mL) and three-fold higher than in controls (0.07+/-0.01 ng/mL; p<0.0001). Negative correlations were found between TAS and 8-OHdG (r=-0.754, p<0.0001) in patients before therapy and positive correlations were found between creatine kinase (CK) and 8-OHdG (r=0.488, p<0.001) and liver enzymes after isotretinoine exposure [4].
Degeneration of bone mass in all exposed human acne subjects
A degeneration of bone mass was seen in all human subjects examined that were exposed to the toxin. Bone density at the Ward triangle decreased a mean of 4.4% (P = .03) after 6 months of isotretinoin exposure (1 mg/kg of body weight) [2].
Slowed rhodospsin regeneration
Even a single dose of isotretinoin slowed the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration was markedly slowed [3].
A strong degeneration of several parts of the body and brain has been found in all examined subjects exposed to (Ro)accutane, whereas it is highly likely that these effects are general. Significantly decreased metabolism in the orbitofrontal cortex was found in all human subjects examined after exposure to (Ro)accutane (-21%) [1].
Picture 1. Bremner JD et al. Functional brain imaging alterations in acne patients treated with isotretinoin. (2005) Am J Psychiatry. May;162(5):983-91.
Doubled oxidative stress measured by 8-OHdG allready at half the maximum dose in acne-subjects
Human subjects with CA (n=18) were evaluated before and 45 days after Iso (0.5mg/kg per day) exposure and non-diseased controls (n=22) were tested only once. Plasma TAS levels and 8-OHdG were measured spectrophotometrically and with an immunoassay, respectively. Liver biochemical parameters and muscle enzymes were measured on a blood chemistry analyzer. Results: TAS levels were significantly (p<0.0001) lower in patients before treatment (921+/-124 mumol/L) compared with those after treatment (1335+/-93 mumol/L) and in controls (1536+/-126 mumol/L). In contrast, 8-OHdG serum levels were two-fold higher in patients after exposure (0.21+/-0.03 ng/mL) than before exposure (0.11+/-0.02 ng/mL) and three-fold higher than in controls (0.07+/-0.01 ng/mL; p<0.0001). Negative correlations were found between TAS and 8-OHdG (r=-0.754, p<0.0001) in patients before therapy and positive correlations were found between creatine kinase (CK) and 8-OHdG (r=0.488, p<0.001) and liver enzymes after isotretinoine exposure [4].
Degeneration of bone mass in all exposed human acne subjects
A degeneration of bone mass was seen in all human subjects examined that were exposed to the toxin. Bone density at the Ward triangle decreased a mean of 4.4% (P = .03) after 6 months of isotretinoin exposure (1 mg/kg of body weight) [2].
Slowed rhodospsin regeneration
Even a single dose of isotretinoin slowed the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration was markedly slowed [3].