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Post by Max on Jul 13, 2005 5:37:32 GMT -5
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Post by Max on Jul 13, 2005 5:37:55 GMT -5
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Post by Max on Jul 13, 2005 5:38:13 GMT -5
References:
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Post by Max on Jul 27, 2005 7:11:47 GMT -5
Diabetes Res Clin Pract. 2005 Jul 16; [Epub ahead of print] Related Articles, Links
Basal production of nitric oxide (NO) and non-NO vasodilators in the forearm microcirculation in Type 2 diabetes: Associations with blood pressure and HDL cholesterol.
Woodman RJ, Playford DA, Watts GF.
School of Public Health, Curtin University of Technology, Perth, Australia.
We examined basal forearm microcirculatory blood flow (FBF) using venous occlusive strain-gauge plethysmography in 47 middle-aged men and women [55+/-1 years] with Type 2 diabetes and 15 age-matched healthy individuals [52+/-3 years], all receiving aspirin. Blood flow was also measured following infusion of N(G)-monomethyl-l-arginine into the brachial artery to inhibit basal NO release (FBF+l-NMMA). Acetylcholine (ACh) and sodium nitroprusside (SNP) were administered to assess endothelium-dependent and endothelium-independent functions. Compared with controls, diabetic subjects had significantly lower vasodilatory responses to ACh and SNP (p<0.05 for each). Basal FBF and FBF+l-NMMA were increased in diabetic subjects compared with controls (2.4+/-0.2ml/100ml/min versus 1.7+/-0.2ml/100ml/min, p=0.02 and 1.9+/-0.1ml/100ml/min versus 1.2+0.1ml/100ml/min, p=0.01, respectively) whereas the change in FBF following l-NMMA was greater in the controls (-27% versus -19%, p=0.05). Amongst the diabetic subjects, pulse pressure and HDL cholesterol were independent predictors of FBF (b=0.04+/-0.01, adjusted r(2)=0.21 and p=0.001, and b=3.3+/-1.2, adjusted r(2)=0.12 and p=0.007, respectively) and FBF+l-NMMA (b=0.03+/-0.01, adjusted r(2)=0.20, p=0.002 and b=2.1+/-0.9, adjusted r(2)=0.09 and p=0.02, respectively). Diastolic blood pressure predicted the change in FBF with l-NMMA (b=-1.02+/-0.32, adjusted r(2)=0.20 and p=0.003). Our findings suggest that well controlled T2DM patients have impaired agonist-mediated vasodilatation of the forearm resistance arteries that is associated with impaired basal release of nitric oxide but an increase in the release of non-NO vasodilators. The latter may be a compensatory response to increased arterial stiffness and may be facilitated by an effect of HDL.
PMID: 16029909 [PubMed - as supplied by publisher]
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Post by Max on Jul 30, 2005 7:02:18 GMT -5
Eur J Pharmacol. 2005 Jan 10;507(1-3):311-6. Epub 2004 Nov 23. Related Articles, Links
Hypothyroidism changes adrenoceptor- and muscarinic receptor-mediated blood pressure responses.
Iwata T, Honda H, Matsuda H, Kondo M, Taniguchi J, Miwa T, Kumasaka K, Moroe H, Notoya Y.
Second Department of Physiology, School of Medicine, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo 142-8555, Japan.
Hypothyroidism was induced by the administration of 0.03% methimazole to drinking water for 1, 2 or 6 weeks to study whether there is a change in adrenoceptor- and muscarinic receptor-mediated blood pressure responses in hypothyroid rats. After 1, 2 and 6 weeks of treatment, the pressor response to norepinephrine was progressively suppressed, and after 6 weeks a significant suppression was observed as compared to control. The depressor response induced by isoprenaline, acetylcholine or sodium nitroprusside was not significantly different between control and hypothyroid rats at any time. The pressor response induced by N(G)-nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide (NO) synthase, was significantly reduced in hypothyroid rats after 1, 2 or 6 weeks of treatment, and the magnitude of the reduction was almost the same for three groups. These results indicated that hypothyroidism causes a time-dependent decrease in pressor responses mediated by alpha-adrenoceptors, but a time-independent decrease in those induced by L-NOARG, and suggest that a progressive decrease in alpha-adrenoceptor-mediated pressor responses occurs in hypothyroidism; however, the decrease in basal NO production and/or release in the peripheral vasculature already occurs in hypothyroid rats at an early stage of the disease.
PMID: 15659322 [PubMed - indexed for MEDLINE]
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Post by hjfjh on Sept 7, 2018 19:47:11 GMT -5
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