Post by Max on Jul 17, 2005 15:26:52 GMT -5
Lower back pain suggested to be due to (Ro)accutane induced effects on retinoid signaling in the spinal cord
Several case reports describe back pain in association with (Ro)accutane exposure. Lower back pain was reported early in about 30% of patients (124) [1].
Lower back pain has been detected as a symptom in human subjects that have a dysfunctional spinal cord [2 and more]. Cells in the spinal cord have been demonstrated to be highly dependent on retinoid signaling in adult human subjects [3 and more]. Also the retinoid receptors are found to be widely expressed in the adult mammalian spinal cord [4 and more]. All PPAR (alpha, beta/delta and gamma) and RXR (alpha, beta and gamma) isotypes were detected and found to exhibit specific patterns of localization in the different areas of the rat brain and spinal cord [4]. An increase in COX-2 expression in the lumbar spinal cord was observed in animals exposed to ATRA [5].
Lower back pain is suggested to be yet another symptom demonstrating (Ro)accutane induced effects on the CNS and peripheral nervous system.
Several case reports describe back pain in association with (Ro)accutane exposure. Lower back pain was reported early in about 30% of patients (124) [1].
Lower back pain has been detected as a symptom in human subjects that have a dysfunctional spinal cord [2 and more]. Cells in the spinal cord have been demonstrated to be highly dependent on retinoid signaling in adult human subjects [3 and more]. Also the retinoid receptors are found to be widely expressed in the adult mammalian spinal cord [4 and more]. All PPAR (alpha, beta/delta and gamma) and RXR (alpha, beta and gamma) isotypes were detected and found to exhibit specific patterns of localization in the different areas of the rat brain and spinal cord [4]. An increase in COX-2 expression in the lumbar spinal cord was observed in animals exposed to ATRA [5].
Lower back pain is suggested to be yet another symptom demonstrating (Ro)accutane induced effects on the CNS and peripheral nervous system.