(Ro)accutane and orbitofrontal cortex metabolism

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Significant decrease in metabolism in orbitofrontal cortex in (Ro)accutane exposed human subjects




Picture 1. Bremner JD et al. Functional brain imaging alterations in acne patients treated with isotretinoin. (2005) Am J Psychiatry. May;162(5):983-91.



Function of the orbitofrontal cortex






References:

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ISOTRETINOIN and depression risk : suggestion to reproduct study about this hypothesis, in order to infirm or confirm it.

cf mail sent to pharmaco-epidemiologics searchers :
www.cjoint.com/doc/18_08/HHDvpcJ5fSb_IsotretinoineMail-.pdf
. in open texte :
www.cjoint.com/c/HGzoz6KDvvb


- ALL THIS SITE IS IN THIS PDF : Last version of "State of the knowledge about the side effects of Roaccutane
(isotretinoin): review of the scientific literature":
www.cjoint.com/doc/18_08/HHDvuUoSvXb_-ScientificStudiesOnIsotretinoinCompleted.pdf
. in open texte :
www.cjoint.com/c/HGyw0KRNVNj
informations of english wikipédia and traduct in french ( to integrate):
www.cjoint.com/doc/18_09/HIhwCR37gZb_ar13ciswikienglishtraductionfran%C3%A7ais.pdf


- last version of french abstract :
www.cjoint.com/doc/18_08/HHviDebLU2b_HGyxgkr8vij-résuméétatsdesconnaissancessurlisotretinoine.pdf
. in open texte :
www.cjoint.com/c/HGyxgkr8vij

- english abstract :
www.cjoint.com/doc/18_07/HGxqLx3KRPj_7777StateOfTheKnowledgeAboutIsotretinoinAbstract7777.pdf
. in open texte
www.cjoint.com/c/HGyw2ZHughj


- extrapolation of Swissmédics data ( french):
www.cjoint.com/doc/18_07/HGxu63wZYij_ExtrapolationStatistiquesSwissm%C3%A9dic2012.pdf
. open texte :
www.cjoint.com/c/HGywYwNXEYj


- extrapolation of Swissmédics data ( english):
www.cjoint.com/doc/18_07/HGxuQI7XCVj_StatisticCalculPharmacovigilance.pdf
open texte :
www.cjoint.com/c/HGyw6ztm3dj