Post by Max on Jul 12, 2005 16:27:34 GMT -5
There are frequent case reports of muscle damage and loss of muscle mass in association with (Ro)accutane exposure in human subjects [3]. The underlying causes are likely several. There is no data of long term effects on ratios of muscle mass or muscular dystrophy compared to control in subjects exposed to the toxin. A long-term relative loss of muscle mass is here suggested.
Loss of muscle mass through inhibition of laminin mediated structural changes in the muscle extracellular matrix
Laminin-2, is found to be essential for the structural integrity of muscle extracellular matrix, and a modulation of laminin results in muscle dystrophy [1]. Retinoic acid exposure decreased the synthesis of fibronectin and laminin and inhibited the migration of all three mesotheliomas on substrates of fibronectin and laminin of three mesothelioma cell cultures of different histotype [2].
Loss of muscle mass through inhibition of laminin mediated structural changes in the muscle extracellular matrix
Laminin-2, is found to be essential for the structural integrity of muscle extracellular matrix, and a modulation of laminin results in muscle dystrophy [1]. Retinoic acid exposure decreased the synthesis of fibronectin and laminin and inhibited the migration of all three mesotheliomas on substrates of fibronectin and laminin of three mesothelioma cell cultures of different histotype [2].