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Post by Max on Jun 13, 2005 18:49:00 GMT -5
A loss of bone density in all acne-subjects exposed to (Ro)accutane can be expected. Compared with that in healthy control subjects, mean bone density was lower at all sites (spine, femoral neck, and Ward triangle) and was considerably more variable at the spine in young men with cystic acne even before treatment. Bone density at the Ward triangle decreased a mean of 4.4% (P = .03) after 6 months of isotretinoin use (1 mg/kg of body weight). Four patients showed decreased density of more than 9% at the Ward triangle. The difference between the mean change in bone density in the patient group and in the control group was significant at the Ward triangle (P = .04) but not at the other sites [1].
Hoffman la Roche itself has reported bone demineralization in associtation with exposure of (Ro)accutane in human subjects [0].
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Post by Max on Jun 22, 2005 6:57:27 GMT -5
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Post by Max on Jul 5, 2005 8:10:24 GMT -5
References:[0] No author Roche official complete US Accutane Product information www.rocheusa.com/products/accutane/pi.pdf [1] Leachman SA, Insogna KL, Katz L, Ellison A, Milstone LM. Bone densities in patients receiving isotretinoin for cystic acne. (1999) Arch Dermatol. Aug;135(8):961-5. FASEB J. 2003 Feb;17(2):247-9. Epub 2002 Dec 3. Related Articles, Links Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. Leheste JR, Melsen F, Wellner M, Jansen P, Schlichting U, Renner-Muller I, Andreassen TT, Wolf E, Bachmann S, Nykjaer A, Willnow TE. Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany. Megalin is an endocytic receptor highly expressed in the proximal tubules of the kidney. Recently, we demonstrated that this receptor is essential for the renal uptake and conversion of 25-OH vitamin D3 to 1,25-(OH)2 vitamin D3, a central step in vitamin D and bone metabolism. Unfortunately, the perinatal lethality of the conventional megalin knockout mouse model precluded the detailed analysis of the significance of megalin for calcium homeostasis and bone turnover in vivo. Here, we have generated a new mouse model with conditional inactivation of the megalin gene in the kidney by using Cre recombinase. Animals with a renal-specific receptor gene defect were viable and fertile. However, lack of receptor expression in the kidney results in plasma vitamin D deficiency, in hypocalcemia and in severe bone disease, characterized by a decrease in bone mineral content, an increase in osteoid surfaces, and a lack of mineralizing activity. These features are consistent with osteomalacia (softening of the bones) as a consequence of hypovitaminosis D and demonstrate the crucial importance of the megalin pathway for systemic calcium homeostasis and bone metabolism. PMID: 12475886 [PubMed - indexed for MEDLINE]
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Post by kjfkfhk on Sept 7, 2018 19:35:47 GMT -5
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