Post by Max on Jul 8, 2005 7:24:43 GMT -5
Hoffman la Roche itself includes "suicide suicide ideation suicide attempt and suicide" in associtation with (Ro)accutane exposure in human acne-subjects [0]. There are several case reports of human subjects that develop impulsive suicidal thoughts, ideations and completed suicides during (Ro)accutane exposure [1, 2, 3 and more].
Forced swim-tests in rat have shown alterations in behaviour, suggesting that (Ro)accutane may alter mechanisms important for the subjects will of survival [4].
There are no post market studies following up suicides that are likely to take place in the years following (Ro)accutane exposure, but it is here suggested that suicides may develop years after exposure as a direct consequence of continous suicidal thoughts, a progressively worsening condition, drastical loss of quality of life (QoL) or post-exposure development of suicidal thoughts, and therefore a (Ro)accutane induced suicide is likely to occur during exposure but also post exposure.
Forced swim-tests in rat have shown alterations in behaviour, suggesting that (Ro)accutane may alter mechanisms important for the subjects will of survival [4].
There are no post market studies following up suicides that are likely to take place in the years following (Ro)accutane exposure, but it is here suggested that suicides may develop years after exposure as a direct consequence of continous suicidal thoughts, a progressively worsening condition, drastical loss of quality of life (QoL) or post-exposure development of suicidal thoughts, and therefore a (Ro)accutane induced suicide is likely to occur during exposure but also post exposure.
