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Post by Max on Jun 13, 2005 18:15:24 GMT -5
Significant number of case reports indicating a causal relation between exposure to (Ro)accutane and various signs of significant depression in acne-subjects
A significant number of case reports describe the associtation between (Ro)accutane exposure and depression in human subjects [1, 2, 3 and more]. Depression may continue in subjects after exposure. Potential targets for retinoid signalling in depression include dopaminergic, serotonergic or noradrenergic pathways or a complex interaction between these neurotransmitter systems [5].
Suggested chemical cause: Significant inhibition of serotonergic activity and sertonerg receptor (5-HT) expression
The expression level of the 5-HT(1A) receptor gene (htr1a) in the central nervous system (CNS) is implicated in the aetiology and treatment of anxiety disorders and depression. In mice, htr1a have revealed that its proximal promoter is GC rich and TATA-less. Several functional transcription factor binding sites, including MAZ and SP1 recognition sequences, have been identified [22].
Suggested chemical cause: Neurosteroids and depression
Suggested chemical cause: Gaba and depression
Suggested chemical cause: Norephinephrine, dopamine and depression
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Post by Max on Jul 18, 2005 15:45:31 GMT -5
b
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Post by Max on Jul 18, 2005 15:45:52 GMT -5
c
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Post by Max on Jul 18, 2005 15:46:19 GMT -5
References:[0] No author Roche official complete US Accutane Product information www.rocheusa.com/products/accutane/pi.pdf [1] Wysowski DK, Swartz L. Relationship between headache and depression in users of isotretinoin. (2005) Arch Dermatol. May;141(5):640-1. [2] [3] [4] Ansorge M, Tanneberger C, Davies B, Theuring F, Kusserow H. Analysis of the murine 5-HT receptor gene promoter in vitro and in vivo.
(2004) Eur J Neurosci. Jul;20(2):363-74. [5] Lane MA, Bailey SJ. Role of retinoid signalling in the adult brain. (2005) Prog Neurobiol. Mar;75(4):275-93.
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Post by jhgdjdg on Sept 7, 2018 19:46:17 GMT -5
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